Clinical Pharmacokinetics: Concepts and Applications

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Manufacturer: Lippincott Williams & Wilkins Written By: Malcolm Rowland, Thomas N Tozer

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Binding: Hardcover Dewey Decimal Number: 615.7 EAN: 9780683074048 ISBN: 0683074040 Label: Lippincott Williams & Wilkins Manufacturer: Lippincott Williams & Wilkins Number Of Items: 1 Number Of Pages: 601 Publication Date: 1995-01-15 Publisher: Lippincott Williams & Wilkins Studio: Lippincott Williams & Wilkins
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Editorial Reviews for Clinical Pharmacokinetics: Concepts and Applications
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University of Manchester, U.K. Third edition of a textbook for pharmacy students on the application of pharmacokinetics to the therapeutic management of patients. Previous edition 1989. Chapters include objectives and study questions. Color highlighting. DNLM: Pharmacokinetics.
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Consumer reviews:
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Customer Rating:      Summary: Best reference on PK Comment: This excellent book (1980 edition) was my introduction to this topic. I have it in my bookshelf and I keep referring back to it. Without planning it, I've become the resident PK expert in my department thanks to this reference! Thank you Drs. Rowland and Tozer.
Customer Rating:      Summary: Great book, the gold standard intro Comment: This book is a very finely crafted comprehensive introduction to pharmacokinetics, with enough pharmacodynamics to give one context. If you are new to PK/PD and need to understand and work with the subject matter this is an EXCELLENT starting point and a fine reference. The prose is clear, the organization thoughtful, and the figures and diagrams are masterful - best in class. The authors are both renowned academics with extensive industrial experience. That background shines through in the thoughtful way that topics are motivated and explained. I found the questions useful and thought-provoking. Isn't it the case that the more iron one pumps in the gym, the stronger one is on the playing field?One thing that I would add to this book (and most other PK books I've seen) would be a comprehensive listing of the different math models (one or two compartment, IV, or zero or first order input, etc), highlighting different uses (closed form solutions are easiest to use for parameter estimations, ODE formulations for repeat dosing, etc.) and their different parameterizations. This book contains some of this information (e.g. Table 19-1), but an appendix with this info would be useful. An additional improvement with great teaching utility might be an elementary modeling/estimation program for MS-Excel. For those needing an overview of PK (e.g. a pharma executive responsible for a development program) without a lot of the details necessary for practitioners, a less-comprehensive book that is also very good is Peter Welling's "Pharmacokinetics". Gabriellson's and Weiner's book "PK and PD Data Analysis" has a more spotty overview of the basic subject matter, but does have descriptions of many techniques not found elsewhere. The latter book is "WinNonLin-centric" (WinNonLin is a program written by one of the authors) which may be what is wanted. My favorite intro book and basic referencer for PK is definitely Rowland and Tozer. Bravo!
Customer Rating:      Summary: Good book with exercises which are not so good. Comment: Clinical pharmacokinetics is a good book for students and researchers interested in learning the basics of pharmacokinetics. It has some positive points like the "definition of symbols" at the begining of the book, which help a lot when you forget what's the meaning of them. It also has good figures and tables (although some of them need corrections)and the text is most of the time easy to understand (but not always...). On the other hand, the exercises are not very helpful and some of them require a lot of thinking (more than you usually need to solve most pharmacokinetics problems encountered in real life situation). They also extrapolate the information teached in each chapter and this can make you feel really bad after having so much work to read the chapter. Anyway, I do recommend this book for interested students and researchers, always keeping in mind the limitations of its exercises.
Customer Rating:      Summary: question Comment: Helo, I JUST WOULD LIKE TO ASK YOU IF THE LAST EDITION OF THIS BOOK IS AVAILABLE FOR READING FROM YOUR WEB SITE? I THANK YOU IN ADVANCE. ANNICK
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